Here’s another speedup tip for Mac OS X users – get rid of duplicate fonts.
I found my system was spending a lot of time running a process called fontd. Also Photoshop on startup would spend time dealing with fonts. Thankfully the fix is easy.
Use the Font Book application to find and disable duplicate fonts. I’ve done this on both my and my wife’s laptops and it has made a big difference. Photoshop starts up faster and certain applications (I noticed it with Powerpoint) become much more responsive. You’ll find Font Book in the Applications folder.